منابع مشابه
Tumor-free heart repair
Men are less prone to autoimmunity than women thanks to the anti-inflam-matory effect of male sex hormones. But how these androgens, such as testos-terone, exert this effect was a mystery. Dunn and colleagues now report on page 321 that a nuclear hormone receptor that gets boosted by testosterone switches off pro-inflammatory cytokine production in male CD4 + T cells. Androgens are known to shi...
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Embryonic stem cells have the distinct potential for tissue regeneration, including cardiac repair. Their propensity for multilineage differentiation carries, however, the liability of neoplastic growth, impeding therapeutic application. Here, the tumorigenic threat associated with embryonic stem cell transplantation was suppressed by cardiac-restricted transgenic expression of the reprogrammin...
متن کاملTumor-free iPS stem cells for heart cells
when induced pluripotent stem (iPs) cells were first discovered in 2007 there was a huge interest.1,2 The iPs cell technique with a minimal number of embryonic transcription factors could turn skin or any other tissue directly into viable embryonic stem cells. it was amazing to able to so simply to turn mature adult cells back into embryonic stem cells. The discovery also avoided the most diffi...
متن کاملAre Stem Cells the next Therapeutic Tool for Heart Repair?
Cardiovascular disease remains the leading cause of morbidity and mortality in the United States and Europe. In recent years, the understanding that regenerative processes exist at the level of the myocardium, has placed stem cell research at center stage in cardiology. A stem cell is a cell that has the ability to divide (self replicate) for indefinite periods often throughout the life of the ...
متن کاملEpicardium-Derived Heart Repair
In the last decade, cell replacement therapy has emerged as a potential approach to treat patients suffering from myocardial infarction (MI). The transplantation or local stimulation of progenitor cells with the ability to form new cardiac tissue provides a novel strategy to overcome the massive loss of myocardium after MI. In this regard the epicardium, the outer layer of the heart, is a tract...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2007
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.2042iti5